Claudette Colbert

Cleopatra

Warren William

Julius Caesar

Henry Wilcoxon

Marc Antony

Joseph Schildkraut

King Herod

Ian Keith

Octavian

Gertrude Michael

Calpurnia

C. Aubrey Smith

Enobarbus

Irving Pichel

Apollodorus

Edwin Maxwell

Casca

Eleanor Phelps

Charmion

Leonard Mudie

Pothinos

Ferdinand Gottschalk

Glabrio (scenes deleted)

Harry Beresford

Soothsayer

Jayne Regan

Lady Vesta

Lionel Belmore

Fidius

Florence Roberts

Lady Flora

Richard Alexander

General Philodemas

Robert Warwick

General Achillas

Robert Seiter

Aelius (as Robert Manning)

Edgar Dearing

Convict

John Carradine

Roman Citizen/Party Guest/Soldier (uncredited) (voice)

Wilfred Lucas

Roman Greeting Antony (uncredited)

David Niven

Slave (uncredited)