Roberto Benigni

Roberto (segment "Strange to Meet You")

Steven Wright

Steven (segment "Strange to Meet You")

Joie Lee

Good Twin (segment "Twins")

Cinqué Lee

Evil Twin (segment "Twins") / Kitchen Guy (segment "Jack...")

Steve Buscemi

Danny (segment "Twins")

Iggy Pop

Iggy (segment "Somewhere in California")

Tom Waits

Tom (segment "Somewhere in California")

Joseph Rigano

Joe (segment "Those Things'll Kill Ya")

Vinny Vella

Vinny (segment "Those Things'll Kill Ya")

Vinny Vella, Jr.

Vinny Jr. (segment "Those Things'll Kill Ya")

Renee French

Renée (segment "Renée")

Alex Descas

Alex (segment "No Problem")

Isaach De Bankolé

Isaach (segment "No Problem")

Cate Blanchett

Cate / Shelly (segment "Cousins")

Michael Hogan

Waiter (segment "Cousins")

Jack White

Jack (segment "Jack Shows Meg His Tesla Coil")

Meg White

Meg (segment "Jack Shows Meg His Tesla Coil")

Alfred Molina

Alfred (segment "Cousins?")

Steve Coogan

Steve (segment "Cousins?")

The GZA

GZA (segment "Delirium")

RZA

RZA (segment "Delirium")

Bill Murray

Bill Murray (segment "Delirium")

William Rice

Bill (segment "Champagne")

Taylor Mead

Taylor (segment "Champagne") (voice)