Tim Curry

Yegor (voice)

Robert Patrick

Louie (voice)

Kelly Ripa

Nat's Mom (voice)

Trevor Gagnon

Nat (voice)

Philip Bolden

I.Q. (voice)

Nicollette Sheridan

Nadia (voice)

Ed Begley Jr.

Poopchev (voice)

David Gore

Scooter (voice)

Christopher Lloyd

Amos (voice)

Adrienne Barbeau

Scooters Mom (voice)

Buzz Aldrin

Himself

Eddie Frierson

Commander Aldrin

David Cowgill

Commander Collins

Sophie Simpson

Katie (voice)

Sandy Simpson

Commander Armstrong (voice)

Phil Proctor

Senior Official (voice)

Lloyd Sherr

Mission Control 1969 (voice)

Nicholas Guest

Fly Buddy #1 (voice)

Archie Hahn

Fly Buddy #2

Lynnanne Zager

Fly at Launch (voice)

Scott Menville

Butch (voice)

Michael McConnohie

American Newscaster (voice)

Doug Stone

Russian Newscaster (voice)

Jessica Gee-George

Maggot #1 (voice)

Mona Marshall

Maggot #2 (voice)

Barbara Goodson

Maggot #3 (voice)

Gregg Berger

Pale Russian Fly (voice)

Grant George

Pale Russian Fly (voice)

Dean Wein

Additional Voices (voice)

Melora Harte

Additional Voices (voice)

Max Burkholder

Mom's Maggot (voice)