Owen Wilson

Reggie (voice)

Woody Harrelson

Jake (voice)

Amy Poehler

Jenny (voice)

George Takei

S.T.E.V.E. (voice)

Colm Meaney

Myles Standish (voice)

Keith David

Chief Broadbeak (Voice)

Dan Fogler

Governor William Bradford (voice)

Lesley Nicol

Female Pilgrim (voice)

Jimmy Hayward

President of the United States/Ranger/Leatherbeak/Hazmats (voice)

Kaitlyn Maher

President's Daughter (voice)

Carlos Alazraqui

Amos (voice)

Josh Lawson

Gus (Voice)

Dwight Howard

Cold Turkey (Voice)

Danny Carey

Danny (voice)

Carlos Ponce

Narrator/Alejandro (voice)

Robert Beltran

Chief Massasoit (voice)

Scott Mosier

Pizza Dude (voice)