Michael Keaton

John Kelly (aka Johnny Dangerously)

Peter Boyle

Jocko Dundee

Griffin Dunne

Tommy Kelly

Marilu Henner

Lil

Joe Piscopo

Danny Vermin

Maureen Stapleton

Ma Kelly

Dom DeLuise

The Pope

Danny DeVito

Burr

Glynnis O'Connor

Sally

Vincent Schiavelli

Ray Walston

Gabe, the Newsstand Vendor

Sudie Bond

Mary Margaret Catherine Dineen

Ron Carey

Pat

Bob Eubanks

Radio Announcer at Movie Premiere

Jack Nance

Priest

Mike Bacarella

Vito

Byron Thames

Young Johnny

Chuck Hicks

Governor

Hank Garrett

Mayor

Alan Hale Jr.

Desk Sergeant

Taylor Negron

Delivery Man

Joe Flaherty

Deathrow Inmate

Elizabeth Arlen

Girl on Steps

Scott Thomson

Charley

Dick Butkus

Arthur