Jordan Peele

Rell Williams / Oil Dresden

Keegan-Michael Key

Clarence Goobril / Smoke Dresden

Keanu Reeves

Keanu (voice)

Tiffany Haddish

Hi-C

Method Man

Cheddar

Darrell Britt-Gibson

Trunk

Jason Mitchell

Bud

Jamar Malachi Neighbors

Stitches

Luis Guzmán

Bacon

Will Forte

Hulka

Nia Long

Hannah

Rob Huebel

Spencer

Madison Wolfe

Alexis

James Yeargain

Donnie

Richard Holden

Detective Mank

Ian Casselberry

King Diaz

Reginal Varice

Cop #2

Nicholas Hayner

Guard #2

Anna Faris

Self (uncredited)

Sam Medina

Cartel Leader (uncredited)

Gino Galento

Narco Guard (uncredited)

Sue-Lynn Ansari

Dancer (uncredited)