Sandra Bullock

Scarlet Overkill (voice)

Jon Hamm

Herb Overkill (voice)

Michael Keaton

Walter Nelson (voice)

Allison Janney

Madge Nelson (voice)

Steve Coogan

Professor Flux / Tower Guard (voice)

Geoffrey Rush

Narrator (voice)

Steve Carell

Gru (voice)

Hiroyuki Sanada

Sumo (voice)

Carlos Alazraqui

Additional Voices (voice)

Lori Alan

Additional Voices (voice)

Jim Cummings

Additional Voices (voice)

Tara Strong

Additional Voices (voice)