John Barrymore

Riviere

Helen Hayes

Madame Fabian

Clark Gable

Jules

Lionel Barrymore

Robineau

Robert Montgomery

Auguste Pellerin

Myrna Loy

Wife of Brazilian Pilot

William Gargan

Brazilian Pilot

C. Henry Gordon

Daudet

Leslie Fenton

Jules' Radio Operator / Co-Pilot

Harry Beresford

Pierre Roblet

Frank Conroy

Radio Operator

Dorothy Burgess

Pellerin's Girlfriend

Irving Pichel

Dr. Decosta

Helen Jerome Eddy

Worried Mother

Ed Brady

Radio Operator on Telephone (uncredited)

Sidney D'Albrook

Airport Office Employee (uncredited)

Claire Du Brey

Santiago Nurse (uncredited)

Otto Hoffman

Airport Office Clerk (uncredited)

George Irving

Santiago Doctor (uncredited)

Michael Mark

Airport Office Employee (uncredited)

Francis McDonald

Radioman (uncredited)

Louis Natheaux

Radioman (uncredited)