John Barrymore

Riviere

Helen Hayes

Madame Fabian

Clark Gable

Jules

Lionel Barrymore

Robineau

Robert Montgomery

Auguste Pellerin

Myrna Loy

Wife of Brazilian Pilot

William Gargan

Brazilian Pilot

C. Henry Gordon

Daudet

Leslie Fenton

Jules' Radio Operator / Co-Pilot

Frank Conroy

Radio Operator

Dorothy Burgess

Pellerin's Girlfriend

Irving Pichel

Dr. Decosta

Helen Jerome Eddy

Worried Mother

Buster Phelps

Sick Child

Ralf Harolde

Pilot

Marcia Ralston

Nightclub Vamp

Maurice Black

Nightclub Manager (uncredited)

Ed Brady

Radio Operator on Telephone (uncredited)

Claire Du Brey

Santiago Nurse (uncredited)

Otto Hoffman

Airport Office Clerk (uncredited)

George Irving

Santiago Doctor (uncredited)

Wallace MacDonald

Mechanic (uncredited)

Michael Mark

Airport Office Employee (uncredited)

Francis McDonald

Radioman (uncredited)

Louis Natheaux

Radioman (uncredited)

Inez Palange

Simone's Maid (uncredited)

Edward Peil Sr.

Airport Office Employee (uncredited)

Evelyn Selbie

Mother in Window (uncredited)