Ryan Reynolds

Wade Wilson / Deadpool / Juggernaut (voice)

Josh Brolin

Cable

Morena Baccarin

Vanessa

Julian Dennison

Firefist

Zazie Beetz

Domino

T.J. Miller

Weasel

Leslie Uggams

Blind Al

Karan Soni

Dopinder

Brianna Hildebrand

Negasonic Teenage Warhead

Jack Kesy

Black Tom

Eddie Marsan

Headmaster

Shioli Kutsuna

Yukio

Stefan Kapičić

Colossus (voice)

Randal Reeder

Buck

Nikolai Witschl

Head Orderly Frye

Rob Delaney

Peter

Lewis Tan

Shatterstar

Bill Skarsgård

Zeitgeist

Terry Crews

Bedlam

Brad Pitt

Vanisher

Paul Wu

Hong Kong Boss

Robert Maillet

Sluggo

Alan Tudyk

Luke - Redneck #1

Matt Damon

Redneck #2

Michasha Armstrong

Swat Captain (School)

Hayley Sales

Cable's Wife

Islie Hirvonen

Cable's Daughter

Jagua Arneja

Tree Trimmer #1

Gerry South

Tree Trimmer #2

Mike Dopud

Prison Guard

Luke Roessler

Cereal Kid

Tanis Dolman

Neighbor #2

Hunter Dillon

Branding Boy

Sala Baker

Older Firefist

Sonia Sunger

News Reporter (Irene)

Paul Wernick

News Cameraman

Rhett Reese

News Helicopter Pilot

Abiola Uthman

Chinook Pilot

Tony Bailey

Black Tom Gang Member

Alex Kliner

Park Bench Couple

David Leitch

Ground Chuck Mutant

Valencia Budijanto

Zoo Kid

Paul Lazenby

Strip Club Baddie

Noah Beggs

Strip Club Baddie

Andrei Kovski

Strip Club Baddie

Alicia Morton

Vocalist on 'Tomorrow' (voice)

Fred Savage

Fred Savage (uncredited)

Andre Tricoteux

On-Set Colossus (uncredited)

James McAvoy

Charles Xavier / Professor X (uncredited)

Nicholas Hoult

Hank McCoy / Beast (uncredited)

Evan Peters

Peter Maximoff / Quicksilver (uncredited)

Tye Sheridan

Scott Summers / Cyclops (uncredited)

Alexandra Shipp

Ororo Monroe / Storm (uncredited)

Kodi Smit-McPhee

Kurt Wagner / Nightcrawler (uncredited)