Ellen Burstyn

Sara Goldfarb

Jared Leto

Harry Goldfarb

Jennifer Connelly

Marion Silver

Marlon Wayans

Tyrone C. Love

Christopher McDonald

Tappy Tibbons

Louise Lasser

Ada

Marcia Jean Kurtz

Rae

Suzanne Shepherd

Mrs. Scarlini

Mark Margolis

Mr. Rabinowitz

Jack O'Connell

Corn Dog Stand Boss

Ajay Naidu

Mailman

Sean Gullette

Arnold the Shrink

Samia Shoaib

Nurse Mall

Peter Maloney

Dr. Pill

Aliya Campbell

Alice

Denise Dowse

Tyrone's Mother

Abraham Aronofsky

Newspaper Man on Train

James Chinlund

Space Oddity

Olga Merediz

Malin & Block Secretary

Ben Shenkman

Dr. Spencer

Keith David

Big Tim

Dylan Baker

Southern Doctor

Leland Gantt

Ward Attendant Penn

Bill Buell

Court Doctor

Jimmie Ray Weeks

Prison Guard

Gregg Bello

E.R. Doctor

Heather Litteer

Big Tim Party Girl

Stanley B. Herman

Uncle Hank

Hubert Selby Jr.

Laughing Guard

Lianna Pai

Angelic Nurse

Darren Aronofsky

Visitor (uncredited)