Ellen Burstyn

Sara Goldfarb

Jared Leto

Harry Goldfarb

Jennifer Connelly

Marion Silver

Marlon Wayans

Tyrone C. Love

Christopher McDonald

Tappy Tibbons

Louise Lasser

Ada

Marcia Jean Kurtz

Rae

Janet Sarno

Mrs. Pearlman

Suzanne Shepherd

Mrs. Scarlini

Charlotte Aronofsky

Mrs. Miles

Mark Margolis

Mr. Rabinowitz

Michael Kaycheck

Donut Cop

Jack O'Connell

Corn Dog Stand Boss

Chas Mastin

Lyle Russel

Ajay Naidu

Mailman

Sean Gullette

Arnold the Shrink

Samia Shoaib

Nurse Mall

Peter Maloney

Dr. Pill

Aliya Campbell

Alice

Denise Dowse

Tyrone's Mother

Scott Franklin

Jailer (voice)

Abraham Aronofsky

Newspaper Man on Train

James Chinlund

Space Oddity

Olga Merediz

Malin & Block Secretary

Ben Shenkman

Dr. Spencer

Keith David

Big Tim

Dylan Baker

Southern Doctor

Shaun O'Hagan

Ward Attendant Seto

Leland Gantt

Ward Attendant Penn

Bill Buell

Court Doctor

Jimmie Ray Weeks

Prison Guard

Gregg Bello

E.R. Doctor

Henry Stram

ECT Technician

Heather Litteer

Big Tim Party Girl

Stanley B. Herman

Uncle Hank

Eric Cohen

Party Animal

David Seltzer

Party Animal

Hubert Selby Jr.

Laughing Guard

Lianna Pai

Angelic Nurse

Darren Aronofsky

Visitor (uncredited)