Gary Cooper

Wild Bill Hickok

Jean Arthur

Calamity Jane

James Ellison

William "Buffalo Bill" Cody

Charles Bickford

John Lattimer

Helen Burgess

Louisa Cody

Porter Hall

Jack McCall

Paul Harvey

Yellow Hand

Victor Varconi

Painted Horse

John Miljan

General George A. Custer

Frank McGlynn Sr.

Abraham Lincoln

Anthony Quinn

Cheyenne Indian

George 'Gabby' Hayes

Breezy

Mark Strong

Wells Fargo Agent (uncredited)

Frank Albertson

A Young Trooper

Purnell Pratt

Capt. Wood

Fred Kohler

Jake - A Teamster

Charles Judels

Tony - The Barber

Harry Woods

Quartermaster Sergeant

Francis McDonald

A River Gambler

George Ernest

A Boy

Fuzzy Knight

Dave

Everett Brown