Dan Castellaneta

Homer Simpson / Itchy / Barney / Abe Simpson / Stage Manager / Krusty the Clown / Mayor Quimby / Mayor's Aide / Multi-Eyed Squirrel / Panicky Man / Sideshow Mel / Mr. Teeny / EPA Official / Kissing Cop / Bear / Boy on Phone / NSA Worker / Officer / Santa's Little Helper / Squeaky-Voiced Teen (voice)

Julie Kavner

Marge Simpson / Selma Bouvier / Patty Bouvier (voice)

Nancy Cartwright

Bart Simpson / Maggie Simpson / Ralph / Nelson / Todd Flanders / TV Daughter / Woman on Phone (voice)

Yeardley Smith

Lisa Simpson (voice)

Hank Azaria

Professor Frink / Comic Book Guy / Moe / Chief Wiggum / Lou / Carl / Cletus / Bumblebee Man / Male EPA Worker / Dome Depot Announcer / Kissing Cop / Carnival Barker / Counter Man / Apu / Drederick Tatum / Sea Captain / EPA Passenger / Robot / Dr. Nick / Wise Guy (voice)

Harry Shearer

Scratchy / Mr. Burns / Rev. Lovejoy / Ned Flanders / Lenny / Skull / President Arnold Schwarzenegger / Kent Brockman / Principal Skinner / Dr. Hibbert / Smithers / Toll Booth Man / Guard / Otto / Kang (voice)

Tress MacNeille

Sweet Old Lady / Colin / Mrs. Skinner / Nelson's Mother / Pig / Cat Lady / Female EPA Worker / G.P.S. Woman / Cookie Kwan / Lindsey Naegle / TV Son / Medicine Woman / Girl on Phone (voice)

Albert Brooks

Russ Cargill (voice)

Marcia Wallace

Edna Krabappel (voice)

Russi Taylor

Martin Prince (voice)

Phil Rosenthal

TV Dad (voice)

Billie Joe Armstrong

Billie Joe Armstrong (voice)

Tré Cool

Tre Cool (voice)

Joe Mantegna

Fat Tony (voice)

Tom Hanks

Tom Hanks (voice)