Lindsay Lohan

Cady Heron

Rachel McAdams

Regina George

Lizzy Caplan

Janis Ian

Lacey Chabert

Gretchen Wieners

Amanda Seyfried

Karen Smith

Daniel Franzese

Damian

Jonathan Bennett

Aaron Samuels

Tina Fey

Ms. Norbury

Tim Meadows

Mr. Duvall

Ana Gasteyer

Cady's Mom

Neil Flynn

Cady's Dad

Amy Poehler

Mrs. George

Dwayne Hill

Coach Carr

Diego Klattenhoff

Shane Oman

Molly Shanahan

Kristen Hadley

Elana Shilling

Spelling Girl

Jonathan Malen

Kristen's Boyfriend

Miranda Edwards

Michigan Girl

Les Porter

Chemistry Teacher

Eve Crawford

English Teacher

Bathsheba Garnett

German Teacher

Daniel DeSanto

Jason

Alisha Morrison

Lea Edwards

Chris Anton

Huge Guy

Julia Chantrey

Amber D'Alessio

Olympia Lukis

Jessica Lopez

Stefanie Drummond

Bethany Byrd

Kristen Bone

Short Girl

Andreja Punkris

Animal Dancer

Alexandra Stapley

Taylor Wedell

Laura de Carteret

Mrs. Wedell

Dan Willmott

Mr. George

Sharron Matthews

Joan the Secretary

Jill Morrison

Crying Girl

Bruce Hunter

Mathlete Moderator

Tara Shelley

Junior Plastic

David Reale

Glenn Coco (uncredited)

Krysta Carter

Wannabe (uncredited)