Lindsay Lohan

Cady Heron

Rachel McAdams

Regina George

Lizzy Caplan

Janis Ian

Lacey Chabert

Gretchen Wieners

Amanda Seyfried

Karen Smith

Daniel Franzese

Damian

Jonathan Bennett

Aaron Samuels

Rajiv Surendra

Kevin Gnapoor

Tina Fey

Ms. Norbury

Tim Meadows

Mr. Duvall

Ana Gasteyer

Cady's Mom

Neil Flynn

Cady's Dad

Amy Poehler

Mrs. George

Dwayne Hill

Coach Carr

Diego Klattenhoff

Shane Oman

Ely Henry

Homeschooled Boy

Jonathan Malen

Kristen's Boyfriend

Jeff Moser

"Farting" Guy

Miranda Edwards

Michigan Girl

Les Porter

Chemistry Teacher

Eve Crawford

English Teacher

Jack Newman

History Teacher

Bathsheba Garnett

German Teacher

Ky Pham

Trang Pak

Daniel DeSanto

Jason

Alisha Morrison

Lea Edwards

Julia Chantrey

Amber D'Alessio

Olympia Lukis

Jessica Lopez

Stefanie Drummond

Bethany Byrd

Kristen Bone

Short Girl

Alexandra Stapley

Taylor Wedell

Laura de Carteret

Mrs. Wedell

Nicole Crimi

Kylie George

Dan Willmott

Mr. George

Sharron Matthews

Joan the Secretary

Randi Lee Butcher

Skater Girl

Jill Morrison

Crying Girl

Bruce Hunter

Mathlete Moderator

Tara Shelley

Junior Plastic

David Reale

Glenn Coco (uncredited)

Krysta Carter

Wannabe (uncredited)