Michael Angarano

Will Stronghold

Mary Elizabeth Winstead

Gwen Grayson / Royal Pain

Kurt Russell

Steve Stronghold / The Commander

Kelly Preston

Josie Stronghold / Jetstream

Danielle Panabaker

Layla Williams

Bruce Campbell

Coach Boomer

Lynda Carter

Principal Powers

Kevin Heffernan

Ron Wilson, Bus Driver

Dee Jay Daniels

Ethan

Kelly Vitz

Magenta

Loren Berman

Little Larry

Nicholas Braun

Zachary "Zach" Braun / Zack Attack

Steven Strait

Warren Peace

Malika

Penny

Khadijah Haqq McCray

Penny

Jake Sandvig

Lash

Will Harris

Speed

Dustin Ingram

Carbon Copy Kid

Christopher Wynne

News Anchor

Cloris Leachman

Nurse Spex

Jim Rash

Mr. Grayson / Stitches

Dave Foley

Mr. Boy

Kevin McDonald

Mr. Medulla

Lucille Soong

Cook

Tom Kenny

Mr. Timmerman

Jill Talley

Mrs. Timmerman

Patrick Warburton

Royal Pain (voice)

Vakisha Coleman

Student Sidekick (uncredited)

Sean Gordon

Penny's Date (uncredited)

Hans Hernke

Laser-Vision Boy (uncredited)

Jason Maxim

Funky Prom Boy (uncredited)