Whoopi Goldberg

Ranger Margaret (voice)

David Spade

Ranger Frank (voice)

Elizabeth Daily

Tommy Pickles (voice)

Tara Strong

Dilan "Dil" Pickles (voice)

Christine Cavanaugh

Chuckie Finster (voice)

Kath Soucie

Phil / Lil / Betty DeVille (voices)

Cheryl Chase

Angelica Pickles (voice)

Tim Curry

Rex Pester (voice)

Jack Riley

Stuart 'Stu' Pickles (voice)

Busta Rhymes

Reptar Wagon (voice)

Michael Bell

Charles 'Chaz' Finster Sr. / Grandpa Boris Kropotkin / Drew Pickles (voice)

Joe Alaskey

Grandpa Lou Pickles (voice)

Phil Proctor

Howard DeVille / Igor (voice)

Cree Summer

Susie Carmichael (voice)

Tress MacNeille

Charlotte Pickles (voice)

Melanie Chartoff

Didi Pickles / Minka Kropotkin (voice)

Hattie Winston

Lucy Carmichael (voice)

Andrea Martin

Aunt Miriam (voice)

Tony Jay

Dr. Lipschitz (voice)

Abraham Benrubi

Serge (voice)

Gregg Berger

TV Announcer (voice)

Charlie Adler

United Express Driver (voice)

Mary Gross

Female Guest (voice)

Edie McClurg

Nurse (voice)

Roger Clinton, Jr.

Air Crewman (voice)

Margaret Cho

Lt. Klavin (voice)

Iggy Pop

Newborn Baby (singing voice)

Louis Fresse

Newborn Baby (singing voice)

Lisa Loeb

Newborn Baby (singing voice)

Lenny Kravitz

Newborn Baby (singing voice)

Dawn Robinson

Newborn Baby (singing voice)

Lou Rawls

Newborn Baby (singing voice)

Kate Pierson

Newborn Baby (singing voice)

Cindy Wilson

Newborn Baby (singing voice)

Gordon Gano

Newborn Baby (singing voice)

Laurie Anderson

Newborn Baby (singing voice)

Fred Schneider

Newborn Baby (singing voice)

Jakob Dylan

Newborn Baby (singing voice)

Patti Smith

Newborn Baby (singing voice)

Beck

Newborn Baby (singing voice)

Steve Zirnkilton

Reporter (voice)

Frank Welker

Spike / Monkeys / Scar Snout (voice) (uncredited)