Matthew McConaughey

Ron Woodroof

Jennifer Garner

Eve

Jared Leto

Rayon

Denis O'Hare

Dr. Sevard

Steve Zahn

Tucker

Michael O'Neill

Richard Barkley

Dallas Roberts

David Wayne

Griffin Dunne

Dr. Vass

Kevin Rankin

T.J.

Donna DuPlantier

Nurse Frazin

Deneen Tyler

Denise

J.D. Evermore

Clint

Ian Casselberry

Hispanic Orderly

Rick Espaillat

Michael

Lawrence Turner

Foreman

Lucius Falick

Freddie

James DuMont

Rayon's Father

Jane McNeill

Francine Suskind

Don Brady

Tucker's Father

Tony Bentley

Judge

Sean Boyd

Border Agent

Rachel Wulff

News Anchor

Scott Takeda

Mr. Yamata

Joji Yoshida

Dr. Hiroshi

Carl Palmer

FDA Customs Agent

Douglas M. Griffin

Rog

Craig Borten

Quicksilver Cowboy

Henry Frost

Gay Cowboy

Juliet Reeves London

Rodeo Girl (uncredited)

Sarah Eilts

Ron's Hooker (uncredited)

Steffie Grote

The Girl With The Snake Tattoo (uncredited)