Michael Keaton

John Kelly (aka Johnny Dangerously)

Peter Boyle

Jocko Dundee

Griffin Dunne

Tommy Kelly

Marilu Henner

Lil

Maureen Stapleton

Ma Kelly

Dom DeLuise

The Pope

Danny DeVito

Burr

Glynnis O'Connor

Sally

Vincent Schiavelli

Ray Walston

Gabe, the Newsstand Vendor

Ron Carey

Pat

Richard Dimitri

Roman Troy Moroni

Jack Nance

Priest

Mike Bacarella

Vito

Byron Thames

Young Johnny

Chuck Hicks

Governor

Alan Hale Jr.

Desk Sergeant

Taylor Negron

Delivery Man

Scott Thomson

Charley