Joaquin Phoenix

Larry "Doc" Sportello

Josh Brolin

Lt. Det. Christian F. "Bigfoot" Bjornsen

Owen Wilson

Coy Harlingen

Katherine Waterston

Shasta Fay Hepworth

Reese Witherspoon

Deputy D.A. Penny Kimball

Benicio del Toro

Sauncho Smilax

Jena Malone

Hope Harlingen

Hong Chau

Jade

Jeannie Berlin

Aunt Reet

Maya Rudolph

Petunia Leeway

Michael Kenneth Williams

Tariq Khalil

Martin Short

Dr. Rudy Blatnoyd, D.D.S.

Sasha Pieterse

Japonica Fenway

Martin Donovan

Crocker Fenway

Eric Roberts

Michael Z. Wolfmann

Serena Scott Thomas

Sloane Wolfmann

Sam Jaeger

Agent Flatweed

Timothy Simons

Agent Borderline

Jillian Bell

Chlorinda

Catherine Haena Kim

News Reporter

Yvette Yates Redick

Luz

Jack Kelly

Burke Stodger (archive footage)

Belladonna

Clancy Charlock

Alina Gatti

Howdy Doper's Phone Voice (voice)

Elaine Tan

Xandra

Wilson Bethel

LAPD Officer #1

Anders Holm

LAPD Officer #2

Keith Jardine

Puck Beaverton

Peter McRobbie

Adrian Prussia

Samantha Lemole

Golden Fang Mother

Emma Dumont

Zinnia