Seth MacFarlane

Albert

Charlize Theron

Anna

Amanda Seyfried

Louise

Liam Neeson

Clinch

Giovanni Ribisi

Edward

Neil Patrick Harris

Foy

Sarah Silverman

Ruth

Christopher Hagen

George Stark

Wes Studi

Cochise

Matt Clark

Old Prospector

Evan Jones

Lewis

Rex Linn

Sheriff / Narrator

Brett Rickaby

Charlie Blanche

Alex Borstein

Millie

Ralph Garman

Dan

John Aylward

Pastor Wilson

Jay Patterson

Doctor Harper

Amick Byram

Marcus Thornton

Dennis Haskins

Snake Oil Salesman

Christopher Lloyd

Doc Brown

Gilbert Gottfried

Abraham Lincoln

Ewan McGregor

Cowboy at Fair

John Michael Higgins

Dandy #1

Alec Sulkin

Guy at Fair

Tatanka Means

Other Apache

Jean Effron

Elsie Stark

Bob Jesser

Cowboy at Table

Dylan Kenin

Pastor's Son

Jimmy Hart

Photographer

Tait Fletcher

Cowboy #1

Kevin Wiggins

Ruth's Cowboy Client

Jackamoe Buzzell

Other Cowboy

Jeremy Hudson

Barn Dancer

Preston Bailey

12 Year Old Albert (uncredited)

Belle Shouse

12 Year Old Girl (uncredited)

Challen Cates

Female Passenger (uncredited)

Johnny Otto

Cowboy (uncredited)

Mae Whitman

Prostitute (uncredited)

Patrick Stewart

Dream Voice (voice) (uncredited)

Bill Maher

Barn Dance Comedian (uncredited)

Jamie Foxx

Django (uncredited)

Allyn Rachel

Wild Girl (uncredited)

Kaley Cuoco

Woman in the Store (uncredited)

Ryan Reynolds

Man Killed by Clinch in Bar (uncredited)