Joe Alaskey

Erik the Newscaster (voice)

Ken Foree

Luke St. Luke (voice)

Tom Papa

El Superbeasto (voice)

April Winchell

Dame Grace Appleton / Liza / Babs / Dolly / Joan / Gloria / Scripty / Helga Strudel (voice)

Dee Wallace

Trixie (voice)

Laraine Newman

Lefty / Kate / Courtney / Smelga Strudel / Betty Sue Lou (voice)

Cassandra Peterson

Amber (voice)

Jess Harnell

Uncle Carl (voice)

Harland Williams

Gerard the Exterminator (voice)

Rob Paulsen

Michael / Commercial Voice / Bobby Hyde / Commandant Hess / Assistant Cameraman / El Gato / Grossburger / Creature Preacher (voice)

Debra Wilson

Cigarette Girl / Bride Fronkenstein / Female Patron / Stripper in Hall / Telephone Victim / Old Woman (voice)

Tom Klein

Mr. Fly (voice)

Sheri Moon Zombie

Suzi X (voice)

Brian Posehn

Murray (voice)

Tom Kenny

Rover / Otto / Old Man / Herbie (voice)

Dee Bradley Baker

Nazi Zombie (voice)

Paul Giamatti

Dr. Satan (voice)

Geoffrey Lewis

Lenny (voice)

Rosario Dawson

Velvet Von Black (voice)

John DiMaggio

Burt the Spurt (voice)

Jeff Bennett

Nerdy Patron (voice)

Danny Trejo

Rico (voice)

Carlos Alazraqui

Bennie Redriguez (voice)

Tura Satana

Varla (voice)

Bill Moseley

Otis Driftwood (voice)

Rodger Bumpass

Screaming Patron (voice)

Sid Haig

Captain Spaulding (voice)

Charlie Adler

Krongarr / Mooney McMoon / Albino Singer (voice)

Kevin Michael Richardson

Santa Baby (voice)

Daniel Roebuck

Morris Green (voice)

Christopher Corey Smith

Walla Voodoo (voice)

Zach Hanks

Walla Voodoo (voice)

Ezra Weisz

Walla Voodoo (voice)

Karen Strassman

Walla Voodoo (voice)