John Candy

Jack Gable

Mariel Hemingway

Janet Dubois / Louise

Emma Samms

Rachel Hedison / Laura Claybourne

Raymond Burr

Carter Hedison

Dylan Baker

Blake Hedison

Charles Rocket

Ty Hedison

David Rasche

Dr. Paul Kirkwood / Dennis

Andrea Thompson

Nurse Helen Caldwell

Zach Grenier

Mickey

Jerry Orbach

Lou Sherwood

Renée Taylor

Arlene Sherwood

Milt Oberman

Fetterman

Mark Boone Junior

Cable Man

Tony Steedman

Edward

John Michael Bolger

Len

Mark Zuelke

Chauffeur

Dick Durock

Riley

Anthony G. Schmidt

Mason

Peter Bromilow

Auctioneer

Patrick Bristow

Bellboy

Jason Ross-Azikiwe

Manu

Glenn Dixon

Elderly Man

Paul Tuerpe

Waiter

Fred Morsell

Choking Man

Susan Isaacs

Marie

Marvin Kaplan

Typewriter Repairman

Margot Kidder

Woman in Washroom (uncredited)

Tom Mankiewicz

Man on Stretcher (uncredited)

Robert Wagner

Jack Gates (uncredited)