John Wayne

John Chisum

Forrest Tucker

Lawrence Murphy

Christopher George

Dan Nodeen

Ben Johnson

James Pepper

Glenn Corbett

Pat Garrett

Andrew Prine

Alex McSween

Bruce Cabot

Sheriff Brady

Patric Knowles

Henry Tunstall

Richard Jaeckel

Jess Evans

Lynda Day George

Sue McSween

Pamela McMyler

Sallie Chisum

John Agar

Amos Patton

Lloyd Battista

Neemo

Robert Donner

Bradley Morton

Christopher Mitchum

Tom O'Folliard

Edward Faulkner

James J. Dolan

Ray Teal

Justice J.B. Wilson

John Mitchum

Baker

Alan Baxter

Gov. Sam Axtell

Alberto Morin

Juan Delgado

William Bryant

Jeff - Head Wrangler

Pedro Armendáriz Jr.

Ben

John Pickard

Sgt. Braddock

Abraham Sofaer

Chief White Buffalo

Gregg Palmer

Karl Riker

Hank Worden

Stationmaster Elwood

Pedro Gonzalez Gonzalez

Mexican Rancher

Jim Burk

Trace - Wrangler

Bob Morgan

Pegleg on Street

William Conrad

Narrator - Opening Credits (voice) (uncredited)

José Ángel Espinosa 'Ferrusquilla'

Governor's Aide (uncredited)

Cliff Lyons

Wrangler (uncredited)

Josh McLaglen

Young Boy Loading Wagon (uncredited)

Mary McLaglen

Young Girl (uncredited)

Lee Meriwether

Sallie's Mother (picture in Chisum's Pocketwatch) (uncredited)

Chuck Roberson

Trail Herder (uncredited)

José Torvay

Mexican Blacksmith (uncredited)

Henry Wills

Extra (uncredited)