Jenifer Lewis

Jackie Washington

Tim Curry

Edward Whatsett St. John

Tangie Ambrose

Shaniqua Summers Wells (Jackie's Daughter)

Whoopi Goldberg

Nurse Ethyl Washington Rue Owens (Jackie's Sister)

Robert Bailey Jr.

Wilson Wells (Jackie's Grandson)

Tom Arnold

Marvin Pritz (Jackie's Former Manager)

Loretta Devine

Snookie Tate (Jackie's Childhood Friend)

Julie Hagerty

Pammy Dunbar (Infomercial Host)

David Hyde Pierce

Perry (The Deaf Rehearsal Pianist)

Kathy Najimy

Lola Molina (Jackie's Stalker)

Isabel Sanford

Miss Krumes (Jackie's Play Mama)

JoBeth Williams

Jo Face (Jackie's Vocal Coach)

Mary Wilson

Vesta Crotchley (Jackie's Third Grade Teacher)

Reynaldo Rey

Cadillac Johnson (Retired Pimp)

Loren Freeman

Kim (Jackie's Costume Designer)

Richard Lawson

Milkman Summers (Jackie's Ex-Husband #1)

Patti Austin

Patti Austin (Gospel Singer at Peaches' Funeral)

Kyla Pratt

Little Jackie Washington

Johnny Brown

Rev. Eustace Barnett (Pastor, Kinloch Baptist Temple)

Alan Blumenfeld

Ivan (Theatre Manager)

Charles Barkley

Charles Barkley

Diahann Carroll

Diahann Carroll

Eddie Cibrian

Eddie Cibrian

Jackie Collins

Jackie Collins

Don Cornelius

Don Cornelius

Taylor Dayne

Taylor Dayne

Kathy Griffin

Kathy Griffin

Sean Hayes

Sean Hayes

Ricki Lake

Ricki Lake

Howie Mandel

Howie Mandel

Camryn Manheim

Camryn Manheim

Penny Marshall

Penny Marshall

Bette Midler

Bette Midler

Liza Minnelli

Liza Minnelli

Rosie O'Donnell

Rosie O'Donnell

Dolly Parton

Dolly Parton

Donna Pescow

Donna Pescow

Chris Rock

Chris Rock

Eva Marie Saint

Eva Marie Saint

Grace Slick

Grace Slick

Robert Townsend

Robert Townsend

Bruce Vilanch

Bruce Vilanch

Robert Cesario

Anthony (Paranoid Fan)

Freez Luv

Larry (Die-Hard Fan)

Joey Gaynor

Camera Man - St. John's Crew

Jason Kravits

Wimpy Bald Man

Rudy Ray Moore

Bad Guy in Coco Movie

Sophia Santi

Anti-Fur Protester #1

Scot Zeller

Love Goddess Dancer #1

Paul Terrell Clayton

Musician #1

Ski Carr

Bass Player

Tony Brubaker

Fight Biker

Danny Epper

Fight Biker

Bennie Moore

Fight Biker

Manny Perry

Fight Biker

Scott L. Schwartz

Fight Biker