Paul Giamatti

Barney Panofsky

Dustin Hoffman

Izzy Panofsky

Rosamund Pike

Miriam Grant-Panofsky

Minnie Driver

The 2nd Mrs. P

Scott Speedman

Boogie

Rachelle Lefevre

Clara 'Chambers' Charnofsky

Bruce Greenwood

Blair

Mark Addy

Detective O'Hearne

Macha Grenon

Solange

Jake Hoffman

Michael Panofsky

Anna Hopkins

Kate Panofsky

Saul Rubinek

Charnofsky

Harvey Atkin

2nd Mrs. P's Father

Linda Sorensen

2nd Mrs. P's Mother

Brittany Drisdelle

Girl at Cafe

Thomas Trabacchi

Leo

Clé Bennett

Cedric

Paul Gross

Constable O'Malley of the North

Maury Chaykin

Wedding Guest

Larry Day

Bartender at Wedding

Mark Camacho

T / U Productions Executive #1

Harry Strandjofski

Dr. Morty

Atom Egoyan

O'Malley Director #1

David Cronenberg

O'Malley Director #2

Ted Kotcheff

Train Conductor

David Pryde

T / U Productions Executive #1

Paula Jean Hixson

Bartender at Grumpy's

Marica Pellegrinelli

The Countess

Domenico Minutoli

Judge at Rome Wedding

Massimo Wertmüller

Rome Doctor

Howard Jerome

Uncle Irv

Sam Stone

Fundraising Target #1

Pauline Little

The 2nd Mrs. P's Housekeeper

Kyle Switzer

Production Assistant

Rebecca Croll

Receptionist #1

Arthur Holden

Notary

Denys Arcand

Maitre'D at Ritz

Arthur Grosser

Mr. Dalhousie

Ellen David

Massage Parlour Madame

Marina Eva

Leo's Girlfriend

Sandra Lavoie

Barney's One Night Stand

Ivana Shein

Receptionist #2

Mélanie St-Pierre

O'Malley's New Co-Star

Tarah Schwartz

Reporter

Richard J. Lewis

Pathologist

Howard Rosenstein

Cousin Jeff