Kamal Haasan

Rajaraman Venkatraman (Vasool Raja)

Prakash Raj

Dr. Vishwanathan

Prabhu

Vatti

Sneha

Janaki Vishwanathan (Paapu)

Nagesh

Sriman Venkatraman

Rohini Hattangadi

Kasturi

Crazy Mohan

Professor Margabandhu

Karunas

Amit

Jayasurya

Zakir

Malavika

Priya

Ajay Rathnam

Medicine Professor

Kavithalaya Krishnan

Surgery Professor

Nithin Sathya

Neelakandan

Chitra Lakshmanan

Dr. Kalidas

Thalaivasal Vijay

Doctor

Santhana Bharathi

Gangadharan

Kaaka Radhakrishnan

Margabandhu's father

A. K. Veerasamy

Hospital cleaner

Madhan Bob

Mani Raja

Vaiyapuri

Piles Patient

E. Ramadoss

Ward Boy

Karate Raja

Raja's sidekick

Sampath Ram

Raja's sidekick

Meera Krishnan

Mani Raja's wife

Kaajal Pasupathi

Nurse

Boys Rajan

Professor

Yatin Karyekar

Anand

Ragasiya

Dancer in the song "Cheena Thaana"