Owen Wilson

Lightning McQueen (voice)

Michael Caine

Finn McMissile (voice)

Emily Mortimer

Holley Shiftwell (voice)

John Turturro

Francesco Bernoulli (voice)

Joe Mantegna

Grem (voice)

Thomas Kretschmann

Professor Z (voice)

Peter Jacobson

Acer (voice)

Bonnie Hunt

Sally (voice)

Darrell Waltrip

Darrell Cartrip (voice)

David Hobbs

David Hobbscap (voice)

Tony Shalhoub

Luigi (voice)

Jeff Garlin

Otis (voice)

Jason Isaacs

Siddeley / Leland Turbo (voice)

Bruce Campbell

Rod "Torque" Redline (voice)

Stanley Townsend

Victor Hugo / Vladimir Trunkov / Ivan the Tow Truck (voice)

Vanessa Redgrave

The Queen / Mama Topolino (voice)

Bradford Lewis

Tubbs Pacer (voice)

Cheech Marin

Ramone (voice)

Lewis Hamilton

Lewis Hamilton (voice)

Richard Kind

Van (voice)

John Ratzenberger

Mack (voice)

Michael Wallis

Sheriff (voice)