Adam Devine

Ed (voice)

Rachel Bloom

Op (voice)

Zazie Beetz

Dottie (voice)

Ken Jeong

Clarance (voice)

Jim Jefferies

Burnie (voice)

Catherine O'Hara

Alma (voice)

Reggie Watts

Hoss / Ernest Shackleton (voice)

Henry Winkler

Jepson (voice)

Alex Borstein

Mali (voice)

Benedict Wong

Dr. Chung (voice)

Julia Chan

Mrs. Sun / Little Girl (voice)

Tom Hollander

Charles Darwin (voice)

Richard Kind

Wally (voice)

Steve Aoki

Vinny (voice)

Nick Frost

Captain (voice)

Jon Lovitz

Conch (voice)

Maria Bamford

Bo's Mom (voice)

Raymond S. Persi

That Guy / Booby (voice)

Terry Gross

Bomb (voice)

David Silverman

Cyclops / Donut Store Clerk (voice)

Kelly Hu

News Reporter (voice)

Tom Kenny

Mozart / Sled Dogs (voice)

Jason Hightower

Narrator / Sled Dogs (voice)

Kevin Michael Richardson

Sled Dogs (voice)