Matt Damon

Cale Tucker (voice)

Bill Pullman

Captain Korso (voice)

Drew Barrymore

Akima (voice)

John Leguizamo

Gune (voice)

Nathan Lane

Preed (voice)

Janeane Garofalo

Stith (voice)

Ron Perlman

Prof. Sam Tucker (voice)

Alex D. Linz

Young Cale (voice)

Tone Loc

Tek (voice)

Jim Breuer

The Cook (voice)

Jim Cummings

Chowquin (voice)

Charles Rocket

Firrikash (voice)

Ken Hudson Campbell

Po (voice)

Tsai Chin

Old Woman (voice)

Crystal Scales

Drifter Girl (voice)

David L. Lander

Mayor of New Bangkok (voice)

Roger L. Jackson

First alien (voice)

Chris Scarabosio

Queen Drej (voice)

Leslie Hedger

First Human (voice)

Roy Conrad

Second Human (voice)