Emily Blunt

Liza Drake

Chris Evans

Pete Brenner

Catherine O'Hara

Jackie

Andy García

Dr. Neel

Jay Duplass

Larkin

Brian d'Arcy James

Dr. Lydell

Amit Shah

Eric Paley

Chloe Coleman

Phoebe

Aubrey Dollar

Andy

Britt Rentschler

Camille

Chapel Oaks

Daughter

Selena Anduze

Kate

A.K. Benninghofen

Dr. Bowen

Avis-Marie Barnes

Principal

Nicole Sellars

Zanna Presenter

Mandi Christine Kerr

Clinic RN

Andrea Laing

Ellen

Pat Dortch

Nervous Pain Clinic Doctor

Cara Mantella

Admissions Officer

Dustin Lewis

Mr. Jorgenson

Quinn Bozza

Undercover D.E.A.

Donna DuPlantier

Jane Yagoda

Michael Lowry

Neel's Lawyer

David Kronawitter

Dr. Hartigan

Erin Ownbey

Young Jackie

Alan Wells

Gambling Anonymous Doctor

Cliff Lanning

Crooning Doctor

Sharon Conley

Judge Susan Holman

Desmond Phillips

Bartender

Alexis Baca

Pharmaceutical Model (uncredited)