Julia Roberts

Mary Reilly

John Malkovich

Dr. Henry Jekyll / Edward Hyde

George Cole

Mr. Poole

Michael Gambon

Mary’s Father

Glenn Close

Mrs. Farraday

Kathy Staff

Mrs. Kent

Michael Sheen

Bradshaw

Bronagh Gallagher

Annie

Linda Bassett

Mary's Mother

Ciarán Hinds

Sir Danvers Carew

Henry Goodman

Haffinger

Wendy Nottingham

Screaming Girl's Mother

Moya Brady

Young Woman

Emma Griffiths Malin

Young Whore

Sasha Hanau

Young Mary

Richard Leaf

Screaming Girl's Father

Stephen Boxer

Inspector

Tim Barlow

Vicar

Harry Fielder

Man with Beard (uncredited)