Clint Eastwood

Manco

Lee Van Cleef

Col. Douglas Mortimer

Gian Maria Volonté

El Indio

Luigi Pistilli

Groggy, Member of Indio's Gang

Klaus Kinski

Juan Wild - The Hunchback

Joseph Egger

Old Prophet

Mara Krupp

Mary

Benito Stefanelli

Luke 'Hughie'

Aldo Sambrell

Cuchillo

Lorenzo Robledo

Tomaso, Indio's Traitor

Dante Maggio

Carpenter in Cell with El Indio

Diana Rabito

Callaway's Beautiful Girl in Tub

Mario Brega

Niño, Member of Indio's Gang

Werner Abrolat

Slim, Member of Indio's Gang (uncredited)

Frank Braña

Blackie, Member of Indio's Gang (uncredited)

José Canalejas

Chico, Member of Indio's Gang (uncredited)

Ricardo Palacios

Tucumcari Saloon Keeper (uncredited)

Rosemary Dexter

Mortimer's Sister (uncredited)

Peter Lee Lawrence

Mortimer's Brother-in-Law (uncredited)

Bruno Corazzari

Poker Player (uncredited)

Fernando Di Leo

Cigar Smoking Card Player (uncredited)

Sergio Leone

Whistling Bounty Hunter (voice) (uncredited)

Antonio Palombi

Bartender (uncredited)