Cate Blanchett

Bernadette

Billy Crudup

Elgie

Kristen Wiig

Audrey

Judy Greer

Dr. Kurtz

Laurence Fishburne

Paul Jellinek

Zoë Chao

Soo-Lin

James Urbaniak

Agent Marcus Strang

Troian Bellisario

Becky

Kate Burton

Ellen Idelson

Steve Zahn

David Walker

Megan Mullally

Judy Toll

David Paymer

Jay Ross

Patrick Sebes

Tom the Blackberry Guy

Patrick Jordan

Game Show Host

Kate Easton

Tammy Prospective Parent

Thalia Torio

Kennedy

Cherie McClain

News Reporter

Jóhannes Haukur Jóhannesson

Captain J. Rouverol

Claudia Doumit

Iris

Katelyn Statton

Vivian

Brian "Wolfman Black" Bowman

Parent (uncredited)

Gregory Bromfield

Caterer (uncredited)

Kelley Davis

Passenger (uncredited)

Amy Lyn Elliott

Flight Attendant (uncredited)

Joe Fishel

Galer Street School Parent (uncredited)

Edward Pfeifer

Bus Passenger (uncredited)

Kyle Stoltz

Airline Passenger (uncredited)

Lana Young

Elaine the Airline Woman (uncredited)

Jean Zarzour

Passenger (uncredited)