Wesley Snipes

Eric Brooks / Blade

Stephen Dorff

Deacon Frost

Kris Kristofferson

Abraham Whistler

N'Bushe Wright

Dr. Karen Jenson

Donal Logue

Quinn

Udo Kier

Gitano Dragonetti

Arly Jover

Mercury

Traci Lords

Racquel

Kevin Patrick Walls

Officer Krieger

Tim Guinee

Dr. Curtis Webb

Sanaa Lathan

Vanessa Brooks

Eric Edwards

Pearl

Donna Wong

Nurse

Carmen Thomas

Senior Resident

Shannon Lee

Resident

Kenny Johnson

Heatseeking Dennis

Clint Curtis

Creepy Morgue Guy

Judson Scott

Pallantine

Sidney S. Liufau

Japanese Doorman

Keith Leon Williams

Kam

Andray Johnson

Paramedic

Marcus Aurelius

Pragmatic Policeman

John Enos III

Blood Club Bouncer

Eboni 'Chrystal' Adams

Martial Arts Kid

Lyle Conway

Lyle Conway

Freeman White

Menacing Stud

D.V. DeVincentis

Vampire Underling

Marcus Salgado

Frost's Goon

Esau McKnight

Frost's Goon

Erl Van Douglas

Von Esper

Matt Schulze

Crease

Lennox Brown

Pleading Goon

Irena Stepić

Slavic Vampire Lord

Jenya Lano

Russian Woman

Levan Uchaneishvili

Russian Vampire

Nikki DiSanto

Vampire Victim (uncredited)

Ryan Glorioso

Blood Bath Vampire (uncredited)

Jeff Imada

Henchman (uncredited)

Stephen Norrington

Vampire (uncredited)

Gerald Okamura

Vampire (uncredited)

Frankie Ray

Vampire Lord (uncredited)

Ted King

Vampire at rave (uncredited)

Steven Ho

Frost's Goon

Will Leong

Henchman (uncredited)

Al Goto

Henchman (uncredited)