Seth Rogen

Frank / Sergeant Pepper (voice)

Kristen Wiig

Brenda (voice)

Jonah Hill

Carl (voice)

Bill Hader

Firewater / Tequila / El Guaco (voice)

Michael Cera

Barry (voice)

James Franco

Druggie (voice)

Danny McBride

Honey Mustard (voice)

Craig Robinson

Grits (voice)

Paul Rudd

Darren (voice)

Nick Kroll

Douche (voice)

David Krumholtz

Kareem Abdul Lavash (voice)

Edward Norton

Sammy Bagel Jr. (voice)

Salma Hayek Pinault

Teresa Taco (voice)

Conrad Vernon

Toilet Paper / Sauerkraut / Catcall Sausage / Grape #1 / Beer Can / Pop Bottle (voice)

Sam Vincent

Old Pork Sausage / Refried Beans / Sandwich / Pop Tart / Licorice Rope (voice)

Harland Williams

Ketchup / Drug Dealer / Baba Ganoush (voice)

Michael Dobson

Queso (voice)

Meat Loaf

Meatloaf (voice) (uncredited)